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VEGFC
| 别名 | VEGF-C, Flt4 ligand (Flt4-L), vascular endothelial growth factor-related protein |
|---|---|
| Compound Class | Peptide |
| 变动原因 | The active peptide is a non-convalent and anti-parallel homodimer linked by disulphide bonds |
| Species |
Human |
| Related Product | VEGFC |
Summary
| 基因/前体 |
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| 是否批准为药物？ | |||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 别名 | VEGF-C, Flt4 ligand (Flt4-L), vascular endothelial growth factor-related protein |
数据库链接
| UniProtKB | P49767 |
|---|---|
| Wikipedia | VEGFC |
| RCSB PDB Structure | 2X1W |
| Ensembl Gene | ENSG00000150630 |
| CATH/Gene3D | 2.10.90.10 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
|---|---|
| 关联靶标 | kinase insert domain receptor , fms related receptor tyrosine kinase 4 |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
| Peptide Sequence | AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR |
|---|---|
| Post Translation Modifications | Homodimer formed by interchain disulphide bonds between cysteine residues at positions 45 and 54; further disulphide bonds formed between cysteine residues at positions 20 and 62, 51 and 108, and 55 and 100. N-linked glycosylation of asparagine residues at positions 66 and 94; predicted N-linked glycosylation of asparagine at 129 |
危险品化学品经营许可证（带存储）