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IL-9
| 别名 | interleukin-9 |
|---|---|
| Compound Class | Peptide |
| 变动原因 | IL-9 is a pleiotropic cytokine. Th9 cells and/or the IL-9/IL-9 receptor pathway are potential targets for pharmacological intervention in atopic diseases such as asthma and ulcerative colitis. |
| Species |
Human |
| Related Product | IL-9 |
Summary
| 基因/前体 |
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| 是否批准为药物？ | |||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 别名 | interleukin-9 |
数据库链接
| UniProtKB | P15248 |
|---|---|
| Wikipedia | Interleukin_9 |
| Ensembl Gene | ENSG00000145839 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
|---|---|
| 关联靶标 | Interleukin-9 receptor |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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参考文献
| 1. Kaplan MH, Hufford MM, Olson MR. (2015) The development and in vivo function of T helper 9 cells.. Nat Rev Immunol, 15 (5): (295-307). [PMID:25848755] |
结构
| Peptide Sequence | QGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI |
|---|---|
| Post Translation Modifications | Predicted N-linked glycosylation of asparagine resdidues at positions 32, 45, 60 and 96 |
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