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IFN-α4
| 别名 | IFN-alpha-4, interferon alpha-4B, interferon alpha-76, interferon alpha-M1, interferon alpha-4 |
|---|---|
| Compound Class | Peptide |
| 变动原因 | IFN-α4 is a type I IFN. |
| Species |
Human |
| Related Product | IFN-α4 |
Summary
| 基因/前体 |
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| 是否批准为药物？ | |||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 别名 | IFN-alpha-4, interferon alpha-4B, interferon alpha-76, interferon alpha-M1, interferon alpha-4 |
数据库链接
| UniProtKB | P05014 |
|---|---|
| Wikipedia | IFNA4 |
| Ensembl Gene | ENSG00000236637 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
|---|---|
| 关联靶标 | Interferon-α/β receptor |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
| Peptide Sequence | CDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD |
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| Post Translation Modifications | Predicted disulphide bond fromation between cysteine residues at positions 1 and 99, and 29 and 166 |
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