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IFN-α1/13
| 别名 | interferon alpha-1/13, interferon alpha-D, IFN-alpha 1/13, IFN-α1, IFN-α13 |
|---|---|
| Compound Class | Peptide |
| 变动原因 | Interferon-αs are type I IFNs (includes IFNαs, IFN-β, IFN-ε, IFN-κ and IFN-ω). In humans, there are 13 different IFN-α genes , but only 12 functional human IFN-α proteins, since IFN-α1 and IFN-α13 have identical protein sequences despite being encoded by separate genes. |
| Species |
Human Human |
| Related Product | IFN-α1/13 |
Summary
| 基因/前体 |
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| 是否批准为药物？ | ||||||||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | |||||||||||||||
| 别名 | interferon alpha-1/13, interferon alpha-D, IFN-alpha 1/13, IFN-α1, IFN-α13 |
数据库链接
| UniProtKB | P01562 |
|---|---|
| Wikipedia | Interferon,_alpha_1 |
| Ensembl Gene | ENSG00000197919, ENSG00000233816 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 关联靶标 | Interferon-α/β receptor |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
| Peptide Sequence | CDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE |
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| Post Translation Modifications | Phosphylated threonine residue at position 128; predicted disulphide bonds between cysteine residues at positions 1 and 99 and 29 and 139 |
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