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ephrin-A2
| 别名 | EPH-related receptor tyrosine kinase ligand 6, HEK7 ligand, HEK7-L |
|---|---|
| Compound Class | Peptide |
| 变动原因 | From the ephrin A family of glycosylphosphatidylinositol-linked proteins |
| Species |
Human |
| Related Product | ephrin-A2 |
Summary
| 基因/前体 |
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| 是否批准为药物？ | |||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 别名 | EPH-related receptor tyrosine kinase ligand 6, HEK7 ligand, HEK7-L |
数据库链接
| UniProtKB | O43921 |
|---|---|
| Wikipedia | Ephrin-A2 |
| RCSB PDB Structure | 2WO3 |
| Ensembl Gene | ENSG00000099617 |
| CATH/Gene3D | 2.60.40.420 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
| Peptide Sequence | RAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSN |
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| Post Translation Modifications | Disulphide bond formation between cysteine residues at positions 49 and 90, and 78 and 139. Predicted amidation of C-terminal asparagine residue; predicted N-linked glycosylation of asparagine residues at positions 18, 150 and 164 |
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