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B and T lymphocyte attenuator
| 别名 | B- and T-lymphocyte attenuator , B- and T-lymphocyte-associated protein |
|---|---|
| Compound Class | Peptide |
| 变动原因 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. |
| Species |
Human |
| Related Product | B and T lymphocyte attenuator |
Summary
| 基因/前体 |
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| 是否批准为药物？ | |||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 别名 | B- and T-lymphocyte attenuator , B- and T-lymphocyte-associated protein |
数据库链接
| UniProtKB | Q7Z6A9 |
|---|---|
| Wikipedia | BTLA |
| RCSB PDB Structure | 2aw2 |
| Ensembl Gene | ENSG00000186265 |
| Entrez Gene | 151888 |
| CATH/Gene3D | 2.60.40.10 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 关联靶标 | herpes virus entry mediator |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
| Peptide Sequence | KESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTDVKSASERPSKDEMASRPWLLYRLLPLGGLPLLITTCFCLFCCLRRHQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGSEVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS |
|---|---|
| Post Translation Modifications | Predicted N-linked glcosylation of asparagine residues at positions 45, 64 and 80; disulphide bond formation between cysteine residues at positions 4 and 33, 28 and 85, and 42 and 49 |
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