BMP-7
Compound Class | Peptide |
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变动原因 | The active peptide is a disulphide bond-linked homodimer |
Species |
Human |
Related Product | BMP-7 |
Summary
基因/前体 |
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是否批准为药物? | |||||||||||
IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
数据库链接
UniProtKB | P18075 |
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Wikipedia | Bone_morphogenetic_protein_7 |
RCSB PDB Structure | 1m4u |
Ensembl Gene | ENSG00000101144 |
CAS Registry No. | 129805-33-0 |
CATH/Gene3D | 2.10.90.10 |
生物活性
生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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关联靶标 | Bone morphogenetic protein receptors |
临床资料
作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
Peptide Sequence | STGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH |
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Post Translation Modifications | The active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 103 of each chain. Predicted N-linked glycososylation of asparagine residues at positions 10, 29 and 80. Disulphide bond formation between cysteine residues at positions 38 and 104, 67 and 136, and 71 and 138 |