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BMP-10
| Compound Class | Peptide |
|---|---|
| 变动原因 | The active peptide is a disulphide bond-linked homodimer |
| Species |
Human |
| Related Product | BMP-10 |
Summary
| 是否批准为药物？ | |
|---|---|
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
数据库链接
| UniProtKB | O95393 |
|---|---|
| Wikipedia | Bone_morphogenetic_protein_10 |
| Ensembl Gene | ENSG00000163217 |
| CATH/Gene3D | 2.10.90.10 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
|---|---|
| 关联靶标 | Bone morphogenetic protein receptors |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
|---|
结构
| Peptide Sequence | NAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR |
|---|---|
| Post Translation Modifications | The active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 72 of each chain. Predicted disulphide bond formation between cysteine residues at positions 7 and 73, 36 and 105, and 40 and 107 |
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