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TSH
| 别名 | thyroid-stimulating hormone, thyrotropin, Thyrogen® |
|---|---|
| Compound Class | Peptide |
| 变动原因 | The drug thyrotropin alfa is a peptide heterodimer consisting of an α and β subunit and mimics the endogenous peptide hormone. |
| Related Product | TSH |
Summary
| 是否批准为药物？ | (FDA (1953)) |
|---|---|
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 别名 | thyroid-stimulating hormone, thyrotropin, Thyrogen® |
数据库链接
| Wikipedia | Thyroid-stimulating_hormone |
|---|---|
| DrugBank Ligand | DB00024 |
| PEP | tsh |
| GPCRdb Ligand | 3920 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
|---|---|
| 关联靶标 | TSH receptor |
临床资料
| Summary of Clinical Use | Thyrotropin alfa is used to promote the uptake of iodine for more effective radioactive iodine ablation treatment of some thyroid cancers. May also be used as hormone replacement therapy. |
|---|---|
| 作用机制与药效学效应 | Thyrotropin alfa binds to TSH receptors found on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue. |
结构
| Post Translation Modifications | The production of biologically active TSH requires appropriately folded TSHβ and common α subunits that assemble to form the TSH heterodimer. |
|---|
危险品化学品经营许可证（带存储）