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[Hyp³]bradykinin

别名	[hydroxyproline³]-bradykinin, [Hyp³]-bradykinin
Compound Class	Peptide
变动原因	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.
Species	Human
Related Product	[HYP3]-缓激肽

Summary

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
KNG1	kininogen 1	kininogen-1 precursor	Human	KNG, BDK, kininogen, alpha-2-thiol proteinase inhibitor, bradykinin

是否批准为药物？

IUPAC Name

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

别名

[hydroxyproline³]-bradykinin, [Hyp³]-bradykinin

数据库链接

CAS Registry No.	37642-65-2
UniProtKB	P01042
Ensembl Gene	ENSG00000113889
GPCRdb Ligand	3578

生物活性

生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

临床资料

作用机制与药效学效应	Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants . The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis .

结构

Peptide Sequence	RPXGFSPFR
Post Translation Modifications	The third residue, a proline, is hydroxylated (as indicated by X or Hyp).

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